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Updated: May 16, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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化,化和散列选择性宏观培养,以获得III型环素

Jiaming Wang1, Kang Lv2, Yilu Wen1

  • 1Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing, China.

Nature communications
|April 3, 2025
PubMed
概括

这项研究引入了一种新的双催化方法,用于合成奇拉环. 这一过程实现了前所未有的enantio,atrop和 diastereoselective宏循环,同时控制多个奇拉元素.

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