COVID-19感染与精子质量差有关:一个横截面和纵向临床观察研究
Lulu Yuan1,2, Wei Sun3, Zihan Dong4
1Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No.39, Huaxiang Road, Tiexi District, Shenyang, 110022, Liaoning Province, People's Republic of China.
Scientific reports
|April 3, 2025
概括
COVID-19感染通过降低精子质量,包括精子数量,运动性和增加DNA碎片化而对男性生育能力产生负面影响. 这些发现对于管理受病毒影响的男性生育问题至关重要.
科学领域:
- 生殖医学 生殖医学
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- SARS-CoV-2 流行病引发了人们对男性生殖健康潜在影响的担忧.
- 了解COVID-19对精子质量的影响对于生殖医学和患者咨询至关重要.
- 以前的研究表明存在联系,但需要对精子特定参数进行进一步调查.
研究的目的:
- 为了研究COVID-19感染对精子质量的影响.
- 为了量化SARS-CoV-2感染后精子参数变化的程度.
- 为在COVID-19后患者的男性生育能力的临床管理提供数据.
主要方法:
- 这是一项对604名COVID-19后患者的横截面研究,以及对140名感染前后患者的纵向研究.
- 在纵向研究中包括149个未受影响的对照.
- 评估精子数量,运动性 (渐进和总),形态,精子DNA碎片化指数 (DFI) 和染色质不成熟.
主要成果:
- 横截面研究:与对照组相比,COVID-19患者的精子数量显著降低,A级精子百分比,渐进性运动性,总运动性和更高的DFI.
- 纵向研究:感染后,与感染前样本相比,患者表现出精子数量减少,A级精子,渐进性运动能力,总运动能力和DFI增加.
- 在纵向研究中,超过57%的COVID-19患者在感染后的精子度,数量,运动性和DFI的恶化,与对照组不同.
结论:
- COVID-19 感染与多个精子质量参数的显著下降有关.
- 观察到的精子质量的变化表明,这可能会对男性生育能力产生负面影响.
- 这些发现对于临床医生管理COVID-19患者男性生育问题至关重要.
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