使用处方索赔数据库评估与迪佩代-4抑制剂相关的胃肠道症状
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Ayana Funabashi1,2, Hitoshi Ito3, Mamoru Maeda3
1AIN PHARMACIEZ INC, 2-4-30 Higashisapporo 5-jo, Shiroishi-ku, Sapporo, 003- 0005, Hokkaido, Japan.
双基酶-4抑制剂 (DPP-4is) 与胃肠道问题如恶心和便秘有关,而不是抑制酸性. 药剂师应监测患者是否出现这些不良事件,并考虑开处方级联.
科学领域:
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
- 药品安全 药品安全
背景情况:
- 双基化酶-4抑制剂 (DPP-4is) 通常用于糖尿病管理.
- 人们对与DPP-4相关的潜在胃肠道不良事件 (GAEs) 存在担忧,这是由于其因克雷丁活性.
研究的目的:
- 研究DPP-4抑制剂与特定的GAE之间的关联.
- 通知日本社区药剂师关于潜在的GAE和症状治疗,以加强患者干预.
主要方法:
- 处方序列对称性分析 (PSSA) 是使用日本药房索赔数据库 (2018-2022) 进行的.
- 调整的序列比率 (ASRs) 被计算出来,以评估DPP-4is和GAE治疗 (prokinetics,胃酸抑制剂,药) 之间的关联.
- 根据 prokinetic 和胃酸抑制剂的作用机制,进行了子组分析.
主要成果:
- 在所有观察期 (90,180,360天) 中,DPP-4is与原动力学剂和药有显著的关联.
- 在DPP-4is和胃酸抑制剂之间没有发现显著的关联.
- 亚组分析表明DPP-4与恶心和便秘有关,可能是由于功能障碍而不是胃酸分泌的改变.
结论:
- DPP-4 抑制剂与胃肠功能障碍有关,表现为恶心和便秘.
- 该研究发现,在DPP-4i启动后,可能会出现涉及胃肠道药物的处方级联.
- 加强患者随访和仔细评估症状治疗的风险和益处对于管理DPP-4i相关的GAE至关重要.
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