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相关概念视频

Major Hormones and Their Functions01:27

Major Hormones and Their Functions

272
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
272
Regulation of Hormone Secretion01:19

Regulation of Hormone Secretion

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Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
Humoral...
3.0K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

2.5K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.5K
Feedback Loops01:01

Feedback Loops

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In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.
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Hormones of the Pituitary Gland01:27

Hormones of the Pituitary Gland

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The small, pea-sized pituitary gland is located at the base of the brain. It is crucial in regulating various bodily functions, from growth to reproduction. The gland is divided into the anterior lobe and the posterior lobe. The secretory cell clusters in the pars distalis of the anterior pituitary lobe are controlled by hypothalamic regulators and synthesize six primary hormones.
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...
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Hormonal Control of the Ovarian Cycle01:30

Hormonal Control of the Ovarian Cycle

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The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle.  At puberty, GnRH secretion increases in both frequency and...
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相关实验视频

Updated: May 21, 2025

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
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模仿生物节律的生长激素贴片

Jinpeng Han1, Zhaoyuan Wu2, Shumin Zhan2

  • 1State Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang Provincial Key Laboratory for Advanced Drug Delivery Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.

Nature materials
|April 3, 2025
PubMed
概括

一个新的微针贴片在晚上提供生长激素,模仿自然节奏. 这种以生物节律为灵感的方法比每日注射更有效地增强骨生长.

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Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
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Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
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Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
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科学领域:

  • 生物医学工程 生物医学工程
  • 药理学 药理学是指药理学的学科.
  • 内分泌学 在内分泌学.

背景情况:

  • 药物的疗效和副作用受剂量时间的影响.
  • 与身体的自然节奏同步释放药物对于最佳的治疗结果至关重要.
  • 目前的药物输送系统很难有效地模仿生物节奏.

研究的目的:

  • 开发一种以生物节律为灵感的透皮微针贴片,用于生长激素的输送.
  • 创建一个多阶段的药物释放系统,模仿夜间生长激素分泌模式.
  • 为了比较微针贴片与每日皮下注射的疗效.

主要方法:

  • 设计了一种通过皮肤的微针贴片,具有编程的多阶段药物释放 (爆发和延迟模块).
  • 该贴片被设计成模仿人类生长激素分泌的自然昼夜节律.
  • 在大鼠模型和生长激素基因淘汰小鼠中测试了贴片在促进纵向骨生长和改善骨质量的有效性.

主要成果:

  • 与每日注射相比,微针贴片在纵向骨生长方面表现出更强的疗效.
  • 在健康大鼠 (~10毫米) 和生长激素基因淘汰赛小鼠 (~5毫米) 中观察到显著的骨长度增加.
  • 模仿生物节律的释放模式改善了生长激素的生物可用性,并促进了类似胰岛素的生长因子-1的分泌.

结论:

  • 生物节律启发的微针贴片为生长激素治疗提供了更有效的方法.
  • 这种新型的输送系统成功地模仿了天然荷尔蒙分泌模式,增强了治疗效益.
  • 这些发现支持了慢性药理学在改善与生长有关的疾病治疗结果方面的潜力.