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酸化增强的OTUD3 deubiquitination ARID3A促进了胆管癌的进展

Deng-Yong Zhang1, Yan Zhu2, Shuo-Shuo Ma1,3

  • 1Department of General Surgery, The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, China.

Oncogene
|April 3, 2025
PubMed
概括

双化酶OTU域含蛋白3 (OTUD3) 通过稳定ARID3A.A.促进胆管癌 (CCA) 的进展. 这一途径涉及GSK3β对OTUD3的酸化,增强了ARID3A的稳定性,推动了CCA的生长和转移.

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