人类寿命改变了大脑的功能连接体.
Lianglong Sun1,2,3, Tengda Zhao1,2,3, Xinyuan Liang1,2,3
1State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Nature neuroscience
|April 4, 2025
概括
人类大脑的功能连接性在整个生命周期中不断发展. 这项研究揭示了从婴儿期到老年时脑网络的关键变化,为发育和疾病提供了规范性参考.
科学领域:
- 神经科学是一个神经科学.
- 人类大脑发育 人类大脑发育
- 在Connectomics上,我们提供了连接.
背景情况:
- 人类大脑的功能连接性在一生中经历了重大变化.
- 了解这些变化对于识别发育轨迹和衰老过程至关重要.
研究的目的:
- 绘制人类大脑功能连接组的寿命演变图.
- 建立从婴儿期到老年大脑连接的规范性生长曲线.
- 为了确定不同大脑系统的不同成熟时间表.
主要方法:
- 汇集了132个全球站点的33250名个人 (32周的月经后年龄到80岁) 的无任务功能和结构MRI数据.
- 分析了连接体的全球平均值和差异的非线性增长曲线.
- 开发了系统级的大脑图谱,以检查功能分离和区域连接模式.
主要成果:
- 在连接体生长曲线中确定了关键的拐点,在生命的第三和第四十年后期达到顶峰.
- 揭示了不同大脑系统的功能分离的独特成熟时间表.
- 证明区域连接的寿命增长遵循时空空间皮质轴,从传感器运动区域移动到协会区域.
结论:
- 这项研究提供了功能连接组在人类一生中演变的全面地图.
- 这些发现为量化大脑发育,衰老和神经精神疾病的个体变异提供了规范性参考.
- 阐明大脑网络组织中的动态变化,从早期发育到衰老.
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