甜味剂和甜味增强剂的健康影响数据库开发:SWEET项目
Corey E Scott1, Nikoleta Stamataki1, Joanne A Harrold2
1Cargill Core Research and Development, Plymouth, Minnesota, USA.
Nutrition bulletin
|April 4, 2025
概括
一个新的健康影响数据库组织了对甜味剂和甜味增强剂 (S&SE) 的人类临床研究. 本资源汇编了随机对照试验 (RCT),以解决这些糖替代品的安全性和有效性问题.
科学领域:
- 食品科学与技术 食品科学与技术
- 营养与饮食学 营养与饮食学
- 公共卫生 公共卫生
背景情况:
- 甜味剂和甜味增强剂 (S&SE) 广泛用于食品和饮料中作为糖的替代品,提供低卡路里甜味.
- 尽管获得了全球监管批准,但关于S&SEEs的安全性和有效性仍存在持续的问题.
- 同行评审文献中的随机对照试验 (RCT) 提供了关于S&SEs对健康影响的关键数据.
研究的目的:
- 开发一个全面的,公开可访问的S&SEs人类临床研究数据库.
- 组织和集中现有关于S&SEs的研究,以促进进一步的研究.
- 解决对S&SEs健康影响信息结构化存储库的需求.
主要方法:
- 使用Ovid Medline对2000年1月至2024年9月期间发表的RCT进行了系统的文献搜索.
- 应用了符合条件的标准来过出版物,从而产生了一个精选的数据集.
- 在SWEET项目中开发了一个健康影响数据库,可以在网上访问,并根据健康影响标准进行组织.
主要成果:
- 搜索确定了1538个出版物,其中257个符合纳入数据库的资格标准.
- 在每项S&SE的研究数量中观察到显著的变化;例如,苏克拉有63个符合条件的出版物,而其他如酸-乙硫K盐则没有.
- 健康影响数据库可在https://sweetproject.eu/HIdatabase上获得,并以微软Excel电子表格结构.
结论:
- 新开发的健康影响数据库为研究S&SEs的研究人员提供了有价值的,全面的资源.
- 该数据库通过整合人类临床试验数据,促进了系统审查和元分析.
- 它是了解各种甜味剂和甜味增强剂对健康的影响和有效性的关键工具.
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