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通过植物化学物质在体外抗击皮肤衰老

Sara Cruciani¹, Giuseppe Garroni¹, Diletta Serra¹

¹Department of Biomedical Sciences, University of Sassari, Sassari, Italy.

Journal of cellular and molecular medicine

|April 4, 2025

概括

保护皮肤免受紫外线损伤至关重要. 经过测试的含有太阳保护因子 (SPF) 的乳可以防止皮肤过早衰老,减少DNA损伤,并促进皮肤细胞看起来更年轻.

科学领域:

皮肤病学和光生物学.
细胞生物学和分子遗传学.

背景情况:

阳光照射的紫外线 (UV) 辐射会造成严重的皮肤损伤,包括过早衰老,DNA突变和癌症风险增加.
富含抗氧化剂的天然提取物和生物分子在护肤中用于预防和治疗.
有效的阳光保护对于防止不可逆转的皮肤损伤至关重要.

研究的目的:

评估两种太阳保护因子 (SPF) 乳液对人类皮肤细胞的紫外线诱导损伤的保护作用.
评估SPF奶油对细胞衰老,DNA修复和与细胞循环调节相关的基因表达的影响.

主要方法:

人体皮肤纤维细胞 (HFF1),干细胞 (SSC) 和角质细胞 (HaCaT) 用SPF奶油进行了72小时的预处理.
随后,细胞暴露在紫外线下,随后对细胞循环调节者的基因表达分析 (p16,p19,p21,p53,TERT).
测试测量了Beta-galactosidase测定细胞衰老,并评估了抗氧化潜力,以评估自由基清除能力. 还进行了DNA突变分析.

主要成果:

在所有测试的皮肤细胞类型 (HFF1,SSCs,HaCaT) 中,SPF奶油表现出保护作用.
经过治疗的细胞表现出早期衰老的迹象减少,并抵消紫外线诱导的氧化应激.
奶油增强了DNA修复机制,促进了更年轻的细胞表型,减轻了光衰老效应.

结论:

经过测试的SPF奶油有效地保护皮肤细胞免受紫外线引起的损伤和过早衰老.
这些产品具有抗氧化特性,并增强细胞DNA修复,有助于肌肤更年轻的外观.
这些SPF奶油的局部应用有助于预防阳光损伤和保持皮肤健康.

关键词:

抗氧化剂抗氧化剂是一种抗氧化剂.生物活性分子生物活性分子.细胞衰老细胞衰老纤维细胞的细胞.基因表达的基因表达方式修复机制的修复机制皮肤老化皮肤老化干细胞是干细胞的组成部分.

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