微塑料的积累诱导了脑器官和老鼠大脑中由氨酸衍生的神经毒性
Sung Bum Park1, Jeong Hyeon Jo1,2, Seong Soon Kim1
1Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology (KRICT), Daejeon 34114, Republic of Korea.
Biomolecules & therapeutics
|April 4, 2025
概括
微塑料 (MP) 具有神经毒性风险. 较小的MP积聚在脑模型中,降低细胞活力和改变基因表达,这表明MP可能通过kynurenine途径损害神经健康.
科学领域:
- 环境科学 环境科学
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
背景情况:
- 微塑料 (MP) 是广泛存在的污染物,对人类健康产生了新的关注.
- 神经毒性是MP暴露的潜在不良影响.
- 了解MP的积累和大脑中的影响至关重要.
研究的目的:
- 研究MPs在脑器官和小鼠大脑中的积累和神经毒性作用.
- 为了确定MP大小对大脑组织透和细胞活力的影响.
- 阐明MP诱导的神经毒性背后的分子机制.
主要方法:
- 使用了体外大脑器官和体内小鼠模型.
- 使用不同尺寸 (50nm和100nm) 检查了MP透率.
- 评估了有机体活力,进行了总RNA测序,并分析了小鼠大脑中的DNA碎片,炎症标记物和代谢物.
主要成果:
- 较小的MP (50纳米) 比较大的MP (100纳米) 更深入地穿透大脑器官.
- 暴露于50nm的MPs显著降低了有机体活力,并改变了与神经毒性相关的基因表达.
- 在小鼠中,MP暴露导致了DNA碎片化,炎症标记物的增加,以及神经毒性代谢物 (kynurenine,3-hydroxykynurenine) 的升高.
结论:
- 微塑料可以通过kynurenine途径诱导神经毒性和神经炎症.
- 研究结果表明,MPs可以破坏正常的大脑功能,并突出潜在的神经健康风险.
- 需要进一步的研究来了解MP暴露的长期神经后果.
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