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饮食因素与慢性病之间的因果关系:孟德尔的随机化研究
Ya'nan Huang1, Wei Tang1, Jianfeng Yang1
1Department of Radiology, Shaoxing People's Hospital (Shaoxing Hospital of Zhejiang University), Shaoxing, 312000, China.
经常饮酒会增加慢性病 (CKD) 的风险,而奶酪,茶和干果可以提供保护. 油性鱼和干水果等特定食物会影响功能标记物,为CKD预防和管理提供饮食策略.
科学领域:
- 营养流行病学 营养流行病学
- 腎臟病學 (nephrology) 是一種醫學.
- 遗传流行病学遗传流行病学
背景情况:
- 饮食干预对于治疗慢性病至关重要.
- 关于单个食物对CKD风险和进展的具体影响的证据有限.
- 了解这些关系可以指导个性化的饮食建议.
研究的目的:
- 调查18种不同食物的摄入量与患CKD的风险之间的因果关系.
- 检查这些食物摄入量对估计的淋巴细胞过率 (eGFR) 水平的影响,特别是 eGFRcr 和 eGFRcys.
- 为CKD预防和管理提供基于证据的饮食见解.
主要方法:
- 采用双样本门德尔随机化 (MR) 评估食物摄入量与CKD之间的因果关系.
- 使用多种MR方法,包括逆方差加权 (IVW),加权中位数,MR-Egger,简单模式和加权模式.
- 使用科克兰的Q测试和埃格尔的拦截测试进行了灵敏度分析,以确保结果的有效性.
主要成果:
- 频繁饮酒与患CKD的风险增加有关.
- 奶酪,茶和干水果的摄入量与CKD风险有着保护性关联.
- 油性鱼和干水果摄入量与eGFRcys正相关;沙拉/生蔬菜和干水果与eGFRcr.
- 谷物摄入量与eGFRcr.的减少有关.
结论:
- 饮食习惯显著影响CKD风险和功能标志物.
- 奶酪,茶,干果,油性鱼和蔬菜等特定食物对脏健康有潜在的益处.
- 研究结果支持优化饮食策略的风险或已确立的CKD的个体.
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