在儿童多系统炎症综合征 (MUSIC) 研究后的长期结果中CMR发现
Sean M Lang1, Dongngan T Truong2, Andrew J Powell3
1Heart Institute, Cincinnati Children's Hospital Medical Center, OH (S.M.L., M.D.T.).
Circulation. Cardiovascular imaging
|April 4, 2025
概括
儿童多系统炎症综合征 (MIS-C) 患者在使用心脏MRI进行中期随访时,心脏功能障碍和心肌异常的发病率较低. 少数人出现了轻微的残留问题,突出显示需要持续监测.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 心血管成像 - 心血管成像
- 儿童传染病 儿童传染病
背景情况:
- 儿童多系统炎症综合征 (MIS-C) 通常涉及急性心脏并发症.
- MIS-C对心脏功能的长期影响尚不清楚.
- 心脏磁共振 (CMR) 可以评估MIS-C的心肌健康.
研究的目的:
- 在MIS-C患者中描述心肌缩功能和心肌组织特性.
- 为了评估MIS-C患者的大队伍中长期的心脏后果.
- 使用CMR成像用于MIS-C后详细的心脏评估.
主要方法:
- 分析了来自32个北美中心的255名MIS-C患者的263个CMR研究.
- 核心实验室对心室体积,组织特征和冠状动脉进行评估.
- 住院后3个月,6个月和1年的长度评估.
主要成果:
- 左心室功能障碍是轻微的和不常见的 (最初6.7%,随着时间的推移下降).
- 晚期加多增强 (心肌痕) 是罕见的 (0.8%).
- 冠状动脉扩张发生在7.5%的患者中;3.5%符合心肌炎的标准.
结论:
- 中期随访显示,在MIS-C患者中,显著的心脏功能障碍和心肌异常的患病率较低.
- 轻度残留心脏异常可能在少数患者中持续至住院后1年.
- CMR对于评估心脏恢复和识别MIS-C幸存者的潜在长期后果非常有价值.
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