南印度1型糖尿病患者年轻人的骨健康状况
Akhila Bhandarkar1, Nisha Bhavani2, Praveen V Pavithran2
1Department of Endocrinology, K. S Hegde Medical Academy, Nitte University, Deralakatte, Nityanandanagar, Mangalore, Karnataka, India.
Indian journal of endocrinology and metabolism
|April 4, 2025
概括
1型糖尿病 (T1DM) 患者的骨矿物质密度正常,但骨再吸收标志物减少. 骨干肥胖症随着T1DM持续时间的延长而增加,这表明T1DM中骨健康和身体组成的演变.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 骨健康 骨健康 骨健康
背景情况:
- 1型糖尿病 (T1DM) 与骨折风险增加有关.
- 在T1DM患者中肥胖率的上升有助于复杂的代谢特征.
- 关于印度T1DM群体的骨健康和身体组成的数据有限.
研究的目的:
- 为了比较T1DM与健康对照的南印度成年人的骨健康和身体组成.
- 调查T1DM持续时间,血糖控制和身体组成之间的关系.
- 评估T1DM患者的骨循环标志物.
主要方法:
- 双能X射线吸收计 (DXA) 用于评估骨矿物质密度 (BMD) 和身体组成.
- 在T1DM患者中测量了骨循环标记物 (CTX,P1NP),副激素 (PTH) 和25氧维生素D.
- 51名患有T1DM的成年人和52名年龄和性别匹配的健康对照参与了研究.
主要成果:
- 在T1DM患者和对照人群中,腰椎和部的骨质量在T1DM患者和对照人群中相似.
- 与对照组相比,T1DM患者表现出较低的CTX水平 (骨再吸收标记物) (P=0.005).
- 三分之一的T1DM患者患有肥胖症,腹部和干部脂肪%增加与疾病持续时间更长相关 (P=0.013).
结论:
- 患有T1DM的年轻人保持正常的BMD,但显示骨质再吸收减少.
- 骨干肥胖症在患有较长疾病持续时间的T1DM患者中更为普遍.
- 这些发现表明T1DM骨健康和身体组成的潜在变化,可能与改善的血糖管理有关.
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