系统性炎症指标与牛皮之间的关联:来自NHANES的横截面研究
Huizi Xiong1, Zengyang Yu2,3
1Department of Dermatology, The Fourth Affiliated Hospital of Soochow University/Suzhou Dushu Lake Hospital/Medical Center of Soochow University, Suzhou, Jiangsu, China.
系统性炎症指标,特别是中性粒细胞与血小板细胞的比率 (NPAR) 和中性粒细胞与淋巴细胞的比率 (NLR),与美国成年人的牛皮有关. 需要进一步的研究来证实这些发现,并探索潜在的机制.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 牛皮是一种慢性炎症性皮肤疾病,具有潜在的全身影响.
- 系统性炎症越来越多地被认为是各种慢性疾病的促成因素,包括牛皮.
研究的目的:
- 在美国成年人口中调查系统性炎症指标和牛皮之间的关联.
- 评估这些指标与牛皮发病率相关的预测效果.
主要方法:
- 分析了2003-2014年国家健康和营养检查调查 (NHANES) 的16575名成年参与者的数据.
- 使用多变量逻辑回归和非线性曲线拟合来评估牛皮和炎症标记物 (NPAR,NLR,NHR,LHR,PHR,MHR) 之间的关联.
- 执行子组分析和ROC曲线分析以评估预测准确性.
主要成果:
- 在牛皮和NPAR和NLR之间观察到显著的积极关联.
- 每增加10个单位的NPAR与患上牛皮的几率提高90%相关;每增加1个单位的NLR与患上牛皮的几率提高10%.
- 在牛皮和NPAR,NLR和NHR之间确定了非线性关系,具有特定的断点.
- 通过ROC分析,NLR和NPAR在预测牛皮的流行率方面表现出更好的准确性.
结论:
- 这项研究表明NPAR,NLR和牛皮的发生之间存在积极的关联.
- 这些发现表明NPAR和NLR作为牛皮风险指标的潜在实用性.
- 需要进一步的前性研究来证实这些关联并阐明潜在的机制.
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