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相关概念视频

Tumor Immunotherapy01:27

Tumor Immunotherapy

441
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
441
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

609
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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相关实验视频

Updated: May 17, 2025

Generation of Human Chimeric Antigen Receptor Regulatory T Cells
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基于CD28的CAR优化策略的进展.

Sijin Li1,2,3, Yusi Zhou1,2,3, Hairong Wang1,2,3

  • 1Country Cancer Institute, Xuzhou Medical University, Xuzhou, China.

Frontiers in immunology
|April 4, 2025
PubMed
概括

化学抗原受体 (CAR) -T细胞疗法显示出希望,但面临挑战. 在CAR-T细胞中优化CD28协同刺激域可以提高抗瘤疗效,减少副作用,从而改善癌症治疗.

关键词:
汽车 汽车 汽车 汽车CD28 CD28 CD28 CD28 CD28 CD28 CD28 CD28 CD28 CD28 CD28 CD28 CD28 CD28 CD28 CD28 CD28 CD28采用免疫细胞疗法.癌症治疗疗法 癌症治疗具有共同刺激性的分子.

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科学领域:

  • 免疫学 免疫学 免疫学
  • 在瘤学瘤学.
  • 生物技术是生物技术.

背景情况:

  • 化学抗原受体 (CAR) -T细胞疗法是一种快速发展的癌症治疗方法.
  • 第二代CAR-T细胞利用共刺激域进行激活和功能.
  • 在CAR-T细胞中基于CD28的协同刺激虽然强效,但与复发,耐久性问题和不良事件有关.

研究的目的:

  • 审查CD28在CAR-T细胞抗瘤信号传递中的特征和作用.
  • 通过优化CD28动机,探索提高CAR-T细胞疗效的策略.
  • 为改善CAR-T细胞治疗和减少副作用提供理论基础.

主要方法:

  • 审查关于CAR-T细胞治疗和CD28联合刺激的现有文献.
  • 分析涉及CD28信号动机突变的策略.
  • 检查除了共同刺激之外的其他CAR组件的修改.

主要成果:

  • CD28协同刺激分子对于CAR-T细胞激活和抗瘤功能至关重要.
  • 突变CD28信号动机和修改CAR结构显示了增强抗瘤活性的潜力.
  • 优化策略旨在提高疗效并减轻与CAR-T疗法相关的不良反应.

结论:

  • 优化CD28基因和CAR结构是改善CAR-T细胞疗法的有希望的途径.
  • 进一步的研究可能会导致更有效,更安全的CAR-T细胞治疗癌症.
  • 这一审查为开发下一代CAR-T细胞疗法提供了基础.