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清晰细胞细胞癌的分类使用扩散MRI与多模式明显扩散模型

Shuang Wang¹, Tuo Ji², Dan Yu³

¹Department of Radiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.

Frontiers in oncology

|April 4, 2025

概括

多模式明显扩散 (MAD) 模型可以区分低度和高度清晰细胞细胞癌 (ccRCC). 这种非侵入性成像工具对指导治疗决策充满希望.

科学领域:

放射学放射学是一门学科.
在瘤学瘤学.
医疗成像医学成像

背景情况:

清细胞细胞癌 (ccRCC) 的分级对于治疗计划至关重要.
需要准确的非侵入性方法来区分ccRCC等级.

研究的目的:

评估使用多式联接显微扩散 (MAD) 模型参数来区分低级和高级ccRCC的可行性.
将MAD参数的诊断性能与单指数模型的表面扩散系数 (ADC) 进行比较.

主要方法:

对54名ccRCC患者进行了12个b值的扩散权重成像 (DWI).
计算了MAD模型参数 (Dr, Dh, Dui, Df, fr, fh, fui, ff, αh) 的结果.
低级和高级ccRCC组之间的参数进行了比较,ROC曲线评估了诊断性能.

主要成果:

在低级和高级ccRCC之间发现了Dh,fr和αh的显著差异.
ADC值也显示出显著的差异.
Dh,fr和αh的组合实现了最高的诊断准确度 (0.667) 和AUC (0.796),超过了单个参数和ADC.

结论:

MAD扩散模型显示了作为区分ccRCC等级的非侵入性工具的潜力.
这种方法可以帮助进行手术前规划和针对ccRCC的个性化治疗策略.

关键词:

世界卫生组织/国际泌尿病学学会分级系统.清细胞细胞癌是什么?扩散权重成像技术的使用.磁共振成像技术的使用多模式的表面扩散模型.

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