升高的氧化应激标志物作为孤立冠状动脉脱血的独立预测因素
Sadettin S Baysal1, Şahbender Koç2, Kerem Özbek3
1Başakşehir Çam and Sakura City Hospital, Istanbul, Türkiye.
概括
氧化应激在孤立的冠状动脉脱氧 (CAE) 中升高,由较高的总氧化状态 (TOS) 和脂质氧化物 (LOOH) 水平表明. 这表明氧化失衡有助于CAE的发病,因此有必要进行向治疗.
科学领域:
- 心血管研究研究心血管研究
- 生物标记分析 生物标记分析
- 氧化压力研究 研究 氧化压力研究
背景情况:
- 冠状动脉抽血 (CAE) 是一种扩张异常,与冠状动脉疾病 (CAD) 具有共同的特征,但具有不清楚的独立病理生理学.
- 内皮功能障碍和炎症通常与CAE有关.
- 氧化应激在孤立的CAE中的作用需要进一步研究.
研究的目的:
- 评估孤立CAE患者的氧化和抗氧化生物标志物水平.
- 阐明氧化应激在孤立的CAE病原发生中的潜在作用.
主要方法:
- 用正常冠状动脉动脉图进行比较,将48名孤立的CAE患者与32名控制组进行比较.
- 测量的氧化应激标志物:总氧化状态 (TOS),氧化应激指数 (OSI),脂质氧化物 (LOOH).
- 评估的抗氧化剂标志物:偏氧酶-1 (PON1),血清 (CP),自由硫 (SH) 组,总抗氧化剂状态 (TAS).
主要成果:
- 与对照组相比,CAE患者的TOS,OSI和LOOH水平显著更高.
- 两组之间没有观察到TAS,PON1,CP或SH水平的显著差异.
- 吸烟,TOS和hsCRP通过逻辑回归独立预测CAE.
结论:
- 升高的TOS,OSI和LOOH表明在孤立的CAE中存在一种亲氧化状态.
- 抗氧化剂防御在很大程度上没有改变,这表明氧化应激是关键因素.
- 这些发现支持氧化应激在CAE病变发生中的作用,强调了针对氧化失衡的治疗方法的必要性.
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