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用患者衍生的菌体向慢性生物膜感染:在患有左心室辅助器件的患者中进行了体外和体外概念验证研究

Melissa Pitton^1,2, Luca G Valente^1,2,3, Simone Oberhaensli^4,5

¹Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Open forum infectious diseases

|April 4, 2025

概括

个性化菌体疗法成功针对心力衰竭患者的葡萄球菌表皮菌感染,这些患者使用左心室辅助装置 (LVAD). 从患者微生物群中分离出的菌体对LVAD相关的生物膜显示出有效性,验证了这种方法对慢性感染的有效性.

科学领域:

微生物学微生物学
传染性疾病传染性疾病
生物技术是生物技术.

背景情况:

抗菌素耐药性需要新的治疗策略.
用病毒感染细菌的菌体治疗是一种有希望的替代方案.
在健康个体中,从患者微生物群中进行个性化菌体隔离已经得到证实.

研究的目的:

在左心室辅助器件 (LVAD) 患者中验证个性化的菌体治疗管道.
专注于向Staphylococcus epidermidis的菌体,这是LVAD感染的常见原因.
评估患者特异性菌体在慢性感染环境中对S. epidermidis的疗效.

主要方法:

45名LVAD患者在2.5年内被抽取了S. epidermidis.is的样本.
从额头样本中使用S. epidermidis菌株来放大患者特异性菌体.
隔离的菌体的特征和测试与患者的S. epidermidis分离物和生物膜.

主要成果:

在32名患者中检测到S. epidermidis;3人患有驱动线感染.
从8名患者中分离了菌体,其中6个独特的菌体显示了狭窄的宿主范围.
体vB_SepS_BE22专门杀死了与感染相关的S. epidermidis,并减少了生物膜中的细菌负载.

结论:

在LVAD患者的慢性感染中,个性化的菌体治疗方法得到了验证.
从患者自己的微生物群中分离出来的菌体可以作为有效的治疗剂.
这一管道为在脆弱患者群体中对抗S. epidermidis感染提供了潜在的解决方案.

关键词:

生物膜相关的感染左心室辅助器件的使用方法医学微生物学医学微生物学多种药物耐药性斯塔菲洛科克斯表皮菌.个性化的菌体疗法

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