对癌症免疫疗法的合成反应的灵敏检测,由基因同类对驱动

Chuanpeng Dong1,2,3,4,5, Feifei Zhang1,2,3, Emily He1,2,3,6

  • 1Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.

PubMed
概括

这项研究引入了一种计算方法,以寻找称为paralogs的基因对,可以改善癌症免疫疗法. 这些已识别的帕拉洛格对增强了治疗的有效性,即使单个基因的影响很小.

相关概念视频

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.4K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K