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预测患有失常禁食葡萄糖患者的血糖控制与禁食呼吸系统交换比率

Andrea Foppiani^1,2, Federica Sileo^1,2, Francesca Menichetti¹

¹Department of Food, Environmental and Nutritional Sciences (DeFENS), International Center for the Assessment of Nutritional Status and the Development of Dietary Intervention Strategies (ICANS-DIS), University of Milan, Milan 20133, Italy.

Journal of the Endocrine Society

|April 4, 2025

概括

禁食呼吸交换比率 (RER) 可以预测糖尿病前期的结果. 较低的RER,表明脂肪氧化,与更好的葡萄糖控制和生活方式改变后减弱的禁食葡萄糖的解决有关.

科学领域:

代谢健康代谢健康
内分泌学在内分泌学.
临床诊断临床诊断临床诊断

背景情况:

降低代谢灵活性是糖尿病前期的一个标志,但很难从临床上评估.
目前的代谢灵活性评估方法在常规医疗保健中并不实用.

研究的目的:

调查禁食呼吸交换比率 (RER) 与糖尿病前期葡萄糖代谢之间的联系.
为了确定禁食RER是否可以预测生活方式干预后禁食葡萄糖受损的结果.

主要方法:

对10,176个人进行横截面分析,以将禁食RER与葡萄糖代谢标志物相关联.
长度研究86名患有快食葡萄糖受损的患者,分为脂肪氧化 (RER < 0.775) 和葡萄糖氧化 (RER > 0.925) 组.
评估禁食RER对1年生活方式干预后禁食葡萄糖分辨率受损的影响.

主要成果:

在横截面队列中,更高的禁食RER与高的禁食葡萄糖,胰岛素和HOMA-IR相关.
脂肪氧化组显示,禁食葡萄糖显著降低,并且干预后达到正常血糖的几率更高.
这些改善发生在群体之间的体重减轻差异之外.

结论:

禁食RER是葡萄糖代谢和糖尿病前期进展的实际临床指标.
较低的禁食RER,表明脂肪氧化能力增强,预测更好的血糖控制和减弱的禁食葡萄糖的解决.
这一措施为管理糖尿病前期和指导生活方式干预提供了宝贵的见解.

关键词:

禁食呼吸交换比率 (RER) 是指空腹的呼吸交换比率.脂肪氧化过程中的脂肪氧化.葡萄糖的新陈代谢.禁食葡萄糖 (IFG) 功能受损生活方式干预措施代谢灵活性代谢灵活性

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