全球化物耐药性葡萄球菌菌种的流行率. :一个全面的系统审查和元分析
Tahereh Navidifar1, Abbas Zare Banadkouki2,3, Elnaz Parvizi4
1Department of Basic Sciences, Shoushtar Faculty of Medical Sciences, Shoushtar, Iran.
Frontiers in microbiology
|April 4, 2025
概括
包括MRSA在内的Staphylococcus细菌的宏化物耐药性在全球范围内仍然很高,区域差异很大. 研究结果强调需要标准化方法和更新的指导方针,以有效打击抗生素耐药性.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 葡萄球菌种类导致各种感染,MRSA和CoNS由于多药性耐药性而带来重大挑战.
- 像红红素,清红素和亚红素这样的宏类抗生素经常对耐药的葡萄球菌菌株无效.
研究的目的:
- 系统地审查和综合有关Staphylococcus spp.中宏类耐药性流行率的数据.
- 为了确定宏类抗性模式的时间趋势和地理变化.
- 评估测试方法和指导方针对报告的抗性率的影响.
主要方法:
- 在Scopus,PubMed,Web of Science和EMBASE数据库中进行了系统的文献搜索.
- 来自76个国家的223项研究的数据被提取并使用随机效应模型进行分析.
- 小组分析探讨了国家,大陆,物种和测试指南的变化.
主要成果:
- 结合起来,耐药性的流行率为红素的57.3%,克拉里素的52.6%,亚齐素的57.9%.
- 观察到显著的异质性;大洋洲报告的抗红素耐药性最高 (72%),而欧洲的抗红素耐药性最低 (40.7%).
- 耐药性因物种而异 (MRSA和CoNS更高),从2015-2019年到2020-2023年,红色素耐药性略有下降.
结论:
- 在Staphylococcus spp.中具有高和区域性变化的宏类耐药性. 需要全球监控和标准化的方法.
- 有效的管理需要加强公共卫生措施和更新抗生素治疗指南.
- 解决抗生素耐药性的问题对于公共卫生和患者的结果至关重要.
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