口腔状细胞癌患者的野外癌症:系统性审查
Ezhilarasi Sundaram1, Uma Shankar Pal2, Meleti Venkata Sowmya3
1Department of Oral and Maxillofacial Surgery, Faculty of Dental Science, King George Medical University, Lucknow, Uttar Pradesh 226003 India.
Journal of maxillofacial and oral surgery
|April 4, 2025
概括
口腔的野外癌症涉及正常的组织中的分子变化,往往导致复发. Ki-67是识别这些变化和预测患者结果的最可靠的生物标志物.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 口腔病理学 口腔病理学
背景情况:
- 场癌症描述了临床正常组织中的分子变化,由于暴露于致癌物质而增加了口腔癌的风险.
- 这种现象有助于局部复发和初始治疗后第二次主要瘤的发展.
研究的目的:
- 确定口腔领域癌症中最常用的生物标志物.
- 确定这些生物标志物的预后意义.
主要方法:
- 按照PRISMA指南进行了系统审查,搜索了PubMed,科学网和谷歌学者.
- 在独立审查和全文分析后,包括了23篇文章,并使用JBI检查清单进行了偏见评估.
主要成果:
- 通常评估的生物标志物包括Ki-67,p53,cyclin-D1,E-Cadherin,α-SMA,mi-RNAs,染色体多体和基因甲基化.
- Ki-67和p53是最常用的,但Ki-67在识别场变化方面表现出更为确定的作用.
- 基-67是一种既定的独立预后指标,用于局部区域控制和无病生存率.
结论:
- 基-67是口腔场癌症的宝贵生物标志物,提供预后信息.
- 需要进行进一步的前性研究,以充分阐明各种生物标志物对局部区域复发和第二原发性口腔癌的预测作用.
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