使用可穿戴式肠道声音事件发现的自动炎症性肠病检测
Annalisa Baronetto1,2, Sarah Fischer3,4, Markus F Neurath3,4
1Hahn-Schickard, Freiburg, Germany.
Frontiers in digital health
|April 4, 2025
概括
这项研究使用智能T恤来检测炎症性肠病 (IBD) 患者的异常肠声 (BS). 开发的算法在区分IBD患者和健康个体方面取得了高精度,支持潜在的诊断应用.
科学领域:
- 胃肠病学 胃肠病学
- 生物医学工程 生物医学工程
- 机器学习 机器学习
背景情况:
- 炎症性肠道疾病 (IBD) 可以改变肠道声音 (BS) 的特征.
- 传统的听觉可能会错过微妙的BS事件,表明IBD.
- 带有麦克风的智能T恤为持续的腹部声音监测提供了一种新的方法.
研究的目的:
- 开发和验证用于检测罕见肠道声音事件的模式发现算法.
- 调查自动BS检测在分类IBD患者与健康对照中的临床相关性.
- 评估基于BS的分类与IBD疾病活动相关的性能.
主要方法:
- 从24名IBD患者和21名健康对照组中收集了连续的腹部音频录音.
- 基于深度学习的算法被训练为从大约281小时的数据中自动检索肠道声音事件.
- 在检测到的BS事件周围提取的特征被用来训练一个梯度增强分类器用于患者分类.
主要成果:
- BS检测算法实现了接受器运行特征曲线 (AUC) 下的平均面积≥0.83.3.
- 无论使用手动注释的BS还是算法检测的BS,分类性能都是可比的.
- 对分类窗口大小和功能相关性的探索为模型的行为提供了洞察力.
结论:
- 使用模式发现算法自动检索肠道声音显示了支持IBD诊断的巨大潜力.
- 这项技术提供了一种非侵入性方法来监测并可能有助于治疗IBD患者.
- 进一步开发可以将BS分析纳入IBD评估的常规临床实践.
相关概念视频
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
259
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
259
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
101
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
101
01:30Inflammatory Bowel Disease II: Crohn's Disease
134
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
134
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
99
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
99
01:30Serum Laboratory Studies, Stool Test, Breath Test
264
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
264
01:21Inflammatory Bowel Disease V: Surgical Management
69
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
69