在患有PCOS的女性中最大限度地减少OHSS
Sebastian Leathersich1,2,3,4, Caitlin Roche1, Roger Hart1,2,3,5
1Department of Reproductive Medicine, King Edward Memorial Hospital, Subiaco, WA, Australia.
Frontiers in endocrinology
|April 4, 2025
概括
经过体外受精 (IVF) 的多囊性卵巢综合征 (PCOS) 的女性具有卵巢过度刺激综合征 (OHSS) 的高风险. 本综述详细介绍了在试管婴儿治疗期间将PCOS患者的OHSS风险降到最低的策略.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精 (IVF)
- 妇女健康 妇女健康
背景情况:
- 卵巢过度刺激综合征 (OHSS) 是IVF期间卵巢刺激的严重并发症.
- 患有多囊性卵巢综合征 (PCOS) 的女性面临患上OHSS的风险大幅增加.
研究的目的:
- 审查目前的证据,以减轻IVF接受PCOS妇女的OHSS风险的策略.
- 确定在这个高风险人群中优化试管婴儿安全的方法.
主要方法:
- 审查有关OHSS风险减轻策略的现有证据.
- 识别高风险患者和治疗前咨询.
- 具体干预措施的分析,包括甲胺联合治疗,GnRH抗剂/PPOS协议,适当的淋巴激素剂量,GnRH激动剂触发剂,胚胎冷保存和多巴胺激动剂治疗.
主要成果:
- 几种策略可以显著降低PCOS患者的OHSS风险.
- 这些包括特定的药物治疗方案 (甲胺,GnRH抗剂/PPOS),调整淋巴激素剂量,GnRH激动剂触发剂,以及推迟冷胚胎移植.
- 试管成熟 (IVM) 是一种没有OHSS风险的替代方案,但目前活产率较低.
结论:
- 实施已确定的策略可以预防PCOS妇女的显著早期和晚期OHSS.
- 优化高风险PCOS患者的试管婴儿安全性至关重要.
- 目标是为所有患者实现无OHSS的试管婴儿治疗.
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