运动和组织纤维化:治疗潜力和分子机制的最新进展
Zheng Zhao1, Yongjia Zhu2, Dongfeng Wan3
1School of Physical Education, Anyang Normal University, Anyang, Henan, China.
Frontiers in endocrinology
|April 4, 2025
概括
运动通过抑制纤维细胞激活和减少亲纤维细胞因子,显示出治疗组织纤维化的巨大潜力. 这种非药理学方法为治疗纤维菌性疾病提供了一个有希望的策略.
科学领域:
- 生物医学科学 生物医学科学
- 病理学 病理学 病理学
- 运动生理学 运动生理学
背景情况:
- 组织纤维化,以过度的细胞外基质积累为特征,导致器官功能障碍,是许多慢性疾病的标志.
- 目前的抗纤维菌疗法具有有限的疗效和潜在的不良影响.
- 运动正在成为治疗纤维状况的强有力的非药物干预措施.
研究的目的:
- 审查运动在治疗各种形式的组织纤维化中的治疗潜力.
- 阐明运动抗纤维性作用背后的多方面的机制.
主要方法:
- 审查关于运动和组织纤维化现有的科学文献.
- 分析涉及运动介导抗纤维效应的分子和细胞通路.
主要成果:
- 运动直接抑制纤维细胞激活,并减少转化生长因子β (TGF-β) 等亲纤维细胞因子.
- 运动通过改善代谢健康,减少炎症和增强细胞功能,如自和线粒体活动,促进组织修复.
- 运动在心脏,肺,脏,肝脏和骨肌肉纤维化方面已经证明有好处.
结论:
- 运动通过各种生物机制为管理组织纤维化提供了显著的治疗潜力.
- 运动代表了一种有价值的非药物战略,用于综合性纤维化疾病的治疗.
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