石化暴露和表观遗传改变对人类健康的影响
Selvaraj Jayaraman1, Anupriya Eswaran1, Vishnu Priya Veeraraghavan1
1Centre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
Frontiers in toxicology
|April 4, 2025
概括
石化暴露会改变DNA甲基化,影响基因表达和疾病风险. 了解这些表观遗传变化对于开发生物标志物和针对有害废物相关疾病的向疗法至关重要.
科学领域:
- 环境表观遗传学环境表观遗传学
- 毒理学 毒理学 毒理学
- 分子生物学分子生物学
背景情况:
- 石化产品和汽车产生含有各种有机/无机化合物的危险废物,对健康构成风险.
- 诸如DNA甲基化,基因组修饰和microRNA调节之类的表观遗传机制调解了对疾病发展至关重要的基因环境相互作用.
- 石油化学物质暴露导致表观遗传变化的现有研究需要扩展,特别是在先进的基因编辑技术方面.
研究的目的:
- 审查特定的表观遗传过程,重点关注与长时间石油化学暴露相关的DNA甲基化变化.
- 突出表观遗传改变作为生物标志物的作用,用于早期检测和对石化产生的疾病的个性化治疗.
- 探索基因编辑技术和人工智能驱动的放射学在解决与石化相关的健康风险方面的潜力.
主要方法:
- 关于对石油化学物质暴露的反应表观遗传修饰的科学文献的综述.
- 分析特定的DNA甲基化变化,包括LINE-1,Alu元素,FOXP3,IFN-γ和IL-4.
- 讨论新兴技术,如基于CRISPR的基因编辑和人工智能驱动的放射学.
主要成果:
- 长时间的石油化学暴露与特定的DNA甲基化变化有关,例如LINE-1,Alu和FOXP3的脱甲基化,以及IFN-γ和IL-4的改变甲基化.
- 这些DNA甲基化模式可以作为疾病风险评估和早期检测的有价值的生物标志物.
- 克里斯普尔基因编辑和人工智能驱动的放射学分别显示出治疗干预和早期疾病检测的潜力.
结论:
- 表观遗传变化,特别是DNA甲基化变化,是石油化学物质暴露和相关健康风险的关键指标.
- 需要进一步的研究来完善疾病模型,风险评估和治疗策略,整合计算工具和多omics数据.
- 加强暴露评估和更深入地了解表观遗传修饰对于有效的疾病预防和治疗至关重要.
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