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预防性针在关节置换术后老年患者认知功能上的影响:一项随机对照试验
Qiguo Tu1, Rong Zhou1, Guiping Lv2
1Department of Anesthesiology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China.
Frontiers in medicine
|April 4, 2025
概括
针改善了关节置换患者的认知功能,并减少了术后认知功能障碍. 这种干预可以调节miR-124和miR-146a,抑制神经炎症并保护认知能力.
科学领域:
- 老年医学 老年医学
- 神经外科 神经外科
- 综合医学是一个整体的医学.
背景情况:
- 手术后认知功能障碍 (POCD) 是大骨科手术后老年患者经常出现的并发症.
- 在POCD背后的精确机制仍然不完全理解.
研究的目的:
- 评估预防性针在关节置换手术后减轻认知功能障碍的疗效.
- 调查针可能产生神经保护作用的潜在机制.
主要方法:
- 一项随机对照试验涉及54名接受关节置换的参与者,分别被分配到针或假针组.
- 用蒙特利尔认知评估 (MoCA) 和迷你心理状态检查 (MMSE) 评分来评估认知功能.
- 测量了微RNA (miR) -124,miR-146a和炎症性细胞因子 (TNF-α,IL-6,IL-1β) 的周围血液水平.
主要成果:
- 与假药组相比,针组的MMSE和MoCA得分显著更高,POCD发病率更低.
- 针治疗导致miR-124和miR-146a水平增加,TNF-α,IL-6和IL-1β水平降低.
- 相关性分析显示,升高的miR-124和miR-146a水平与降低的炎症性细胞因子度之间存在关联.
结论:
- 预防性针在接受关节置换的老年患者中对术后认知功能产生保护作用.
- 针可以通过调节miR-124和miR-146a来抑制神经炎症来降低POCD的发生率.
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