乳腺癌患者急性辐射皮肤炎相关的预测因素:一项回顾性队列研究
Rattanaporn Nanthong1,2, Sunanta Tungfung2, Kamonwan Soonklang1,3
1Princess Srisavangavadhana College of Medicine, Chulabhorn Royal Academy, Bangkok, Thailand.
PeerJ
|April 4, 2025
概括
肥胖,局部增强治疗和玻尿酸注射增加了乳腺癌患者中度至重度急性辐射皮炎 (ARD) 的风险. 低分离放射治疗和激素治疗可能会降低ARD的严重程度.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 皮肤病学 皮肤病学
背景情况:
- 急性辐射皮炎 (ARD) 是乳腺癌术后放射治疗 (RT) 的常见副作用.
- ARD可以显著影响患者的生活质量.
研究的目的:
- 在接受RT的乳腺癌患者中,确定与中度至重度ARD相关的预测因素.
主要方法:
- 对2017年1月至2022年12月635名患者数据的回顾性分析.
- 使用放射治疗瘤学小组 (RTOG) 规模评估ARD.
- 使用后勤回归分析来确定风险因素.
主要成果:
- 32%的患者经历了中度至重度的ARD.
- ARD的危险因素包括BMI≥30 kg/m2,局部增强治疗和玻尿酸注射.
- 低分离RT和激素治疗与ARD风险降低有关.
结论:
- 肥胖和特定的治疗方式,如局部增强和玻尿酸应用是ARD的关键风险因素.
- 低分离RT和激素治疗可以减轻ARD的严重程度.
- 结果可以为治疗计划提供信息,以减少ARD风险.
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