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甘草通过减轻内分泌网膜应激和亡来减轻西斯普拉丁诱导的肝毒性

Jie Li¹, Xiujuan Yang¹, Xiaolong Lian²

¹School of Pharmaceutical Science, Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu, China.

Frontiers in pharmacology

|April 4, 2025

概括

甘 (GanCao) 通过减少内分泌网膜应激和亡来保护免受西斯普拉丁诱导的肝损伤. 这项研究阐明了甘在减轻化疗诱导的肝毒性方面的保护机制.

科学领域:

药理学药理学是指药理学的学科.
肝病学肝病学是一种肝病学.
传统中国医药传统中国医药

背景情况:

西斯 (CP) 是一种化疗药物,可导致肝损伤 (肝毒性) 和药物诱导性肝损伤 (DILI).
细胞内膜网膜 (ER) 应激与CP诱导的肝损伤有关,但其确切作用尚未完全理解.
甘草 (GanCao,GC) 是一种传统的中医药,以其保护肝脏的特性而闻名.

研究的目的:

在大鼠模型中研究甘 (GC) 对西斯普拉丁 (CP) 诱导的肝毒性的保护作用.
阐明潜在的机制,重点关注细胞内膜网膜 (ER) 应激和亡途径.

主要方法:

通过使用CP注射建立了DILI的老鼠模型.
进行GC治疗以评估其对肝功能,病理,氧化应激,ER压力标志物和亡的影响.
使用定量实时PCR (qRT-PCR),西式斑点和免疫光 (IF) 来分析肝脏组织和LO2细胞的分子变化.

主要成果:

肝炎治疗显著增加肝酶,导致肝损伤,增加反应性氧物种 (ROS) 和ER压力/亡标志物,包括PERK/ATF4/CHOP通路.
GC治疗显著改善了肝功能,减少了肝损伤和ROS水平.
GC显著抑制了ER压力标记物,亡因子和PERK/ATF4/CHOP通路的表达.

结论:

甘 (GC) 在大鼠中显示出对CP诱导的肝毒性有显著的保护作用.
通过减轻内细胞网膜应激和抑制亡,GC减轻了CP诱导的肝损伤.
这些发现支持GC的治疗潜力,用于管理化疗引起的肝损伤.

关键词:

压力ERER压力ERER压力在PERK/ATF4/CHOP路径中.灭症 (apoptosis) 是一种死亡的过程.肝毒性肝毒性肝毒性甘露是一种甘.

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