达普托米辛在用德克斯特和依可德克斯特林为基础的腹透析溶液中的稳定性
Kai Ming Chow1,2, Siu Kwan Wo3, Simon Wai Yin So4
1Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong.
概括
腹内达普托米辛在各种腹透析溶液中稳定,包括长时间的伊科德克斯. 这项研究指导了在经过腹膜透析并经历抗生素耐药性的患者中安全有效地使用达普托米辛.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗生素耐药性增加需要替代治疗方法,如皮透析 (PD) 患者的达普托米辛.
- 有限的数据存在于常见的PD溶液中的腹膜内达普托米辛稳定性,包括icodextrin和更高度的右糖.
- 了解达普米辛的稳定性对于优化PD治疗方案至关重要.
研究的目的:
- 为了确定不同PD溶液中的腹腔内达普托米辛在不同度中的稳定性.
- 为了确定在环境条件下在标准PD袋中达普托米辛稳定性的持续时间.
- 为了提供基于证据的指导,用于临床使用腹腔内达普托米辛.
主要方法:
- 达普托米辛的稳定性被评估为UltraBag乳糖2.5%,UltraBag冰素7.5%和Stay-Safe Balance2.3%的PD袋.
- 制备了两种达普托米辛度 (维护和加载水平),并在25°C下储存.
- 样品在指定时间点 (长达48小时) 收集,并使用二极管阵列探测器 (HPLC-DAD) 的高性能液态染色学进行分析.
主要成果:
- 在维持度下,达普托米辛在2.5%的乳糖中保持稳定48小时,在7.5%的冰烯和2.3%的Balance中保持稳定24小时.
- 在负载度下,达普托米辛的稳定性在2.5%的德克斯特和2.3%的Balance中持续了12小时,在7.5%的伊科德克斯中持续了48小时.
- 稳定性因PD溶液类型和达普托米辛度而异.
结论:
- 该研究提供了关键的稳定性数据,支持在多种PD溶液中使用腹腔内达普托米辛.
- 这些发现指导了在PD患者中准备和使用达普托米辛治疗腹膜炎的准备和使用.
- 结果可以为临床实践提供信息,可能使得家庭护理对达普米辛的管理提供支持.
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