双杆菌乳杆菌三重活力通过调节肠道微生物群和新陈代谢来缓解缓慢过渡性便秘
Mei Luo1, Peiwei Xie1, Xuehong Deng1
1Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Journal of gastroenterology and hepatology
|April 4, 2025
概括
双菌 Lactobacillus triple viable 通过改善患者的肠道过渡时间和症状,有效治疗缓慢过渡便秘 (STC). 它还通过调节肠道微生物群和新陈代谢来改善大鼠的STC.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 肠道微生物群是功能性便秘 (FC) 病原和治疗的组成部分.
- 缓慢过渡便秘 (STC) 是FC的一个亚型,需要有效的治疗策略.
研究的目的:
- 为了研究Bifidobacterium Lactobacillus三重可活性的治疗疗效在患者和STC.的老鼠模型中.
主要方法:
- 在Bifidobacterium Lactobacillus三重可活性治疗前后对STC患者 (罗马IV标准) 的临床评估,测量胃肠道传输时间 (GITT) 和症状.
- 使用洛佩拉米德诱导STC大鼠模型,然后进行Bifidobacterium Lactobacillus三重可生存治疗,以评估治疗效果和潜在机制.
主要成果:
- 在STC患者中,Bifidobacterium Lactobacillus三重可行的加速GITT和改善关键便秘症状.
- 在STC大鼠中,治疗增强了肠道功能,调节了微生物群,增加了神经递质 (乙胆,5-HT,SP,VIP),增加了便长链脂肪酸 (LCFA),调节了水素和炎症基因表达.
结论:
- 双杆菌 Lactobacillus 三重活力证明了在人类患者和动物模型中对STC的治疗潜力.
- 益生菌在STC中的有效性归因于其调节肠道微生物群和宿主新陈代谢的能力.
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