在患有自闭症谱系障碍的儿童中,社会视觉通路中的休息状态功能连接被破坏
Chenhao Li1, Haesoo Park1, Jitendra Awasthi2
1Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut, USA.
概括
患有自闭症谱系障碍 (ASD) 的儿童在正确的社会视觉通路中显示出大脑连接性降低. 这种低连接性与自闭症谱系障碍中更大的社会挑战有关.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 临床心理学 临床心理学
背景情况:
- 社会视觉路径处理动态的社会信息,与背部路径分离.
- 这条路由从上突 (STS) 的后部到前部部分运行.
- 了解这种途径中的功能连接对于研究神经发育状况,如自闭症谱系障碍 (ASD) 至关重要.
研究的目的:
- 调查自闭症谱系障碍 (ASD) 儿童与典型发育 (TD) 儿童相比,在社会视觉通路内休息状态的功能连接.
- 探索该途径中的功能连接性与ASD中社会症状严重程度之间的关系.
主要方法:
- 利用了静止状态功能连接性分析.
- 从自闭症脑成像数据交换 (ABIDE) 存储库检查的数据.
- 与ASD儿童和TD儿童之间的右半球社会视觉通路中的相比连接模式.
主要成果:
- 与TD儿童相比,在ASD儿童的右半球中,在后部和中间STS (pSTS-mSTS) 之间发现了显著的低连接性.
- 在ASD中观察到pSTS-mSTS连接性和社会症状严重程度之间的负相关性.
- 发现该地区的连接性较低与ASD和TD组中更高的社交沟通脆弱性相关.
结论:
- 右半球社会视觉通路的特定干扰可能会导致ASD儿童的社会困难.
- 在pSTS-mSTS区域的低连接性是自闭症谱系障碍中社会挑战的潜在神经标志物.
- 这些发现强调了正确的社会视觉路径在典型的社会发展中的重要性,以及其在ASD中的变化.
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