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解码结肠直肠癌:揭示了中国人口中的关键基因和途径

Dongbing Li¹, Guizhen Lyu²

¹Scientific Research Center, Beijing ChosenMed Clinical Laboratory Co., Ltd. Beijing, 100176, China.

Current medicinal chemistry

|April 4, 2025

概括

这项研究确定了包括CCL20和CDC20在内的八个关键基因,作为中国人群中结直肠癌 (CRC) 的潜在诊断标志物. 这些发现为CRC提供了新的见解.

科学领域:

基因组学就是基因组学.
在瘤学瘤学.
生物信息学是一种生物信息学.

背景情况:

结肠直肠癌 (CRC) 是全球癌症死亡的主要原因.
基因表达总 (GEO) 数据库是CRC基因组研究的宝贵资源.

研究的目的:

在中国人群中确定与结直肠癌 (CRC) 相关的关键基因和分子途径.
为了发现CRC的潜在诊断生物标志物.

主要方法:

来自GEO数据库的四个中国CRC微阵列数据集的分析,以识别差异表达基因 (DEG).
功能丰富分析 (GO,KEGG) 用于阐明分子机制.
蛋白与蛋白相互作用 (PPI) 网络构建和CytoHubba工具应用以识别关键基因.
使用GEPIA,ONCOMINE和人类蛋白质图谱 (HPA) 数据库进行验证.

主要成果:

在中国CRC中确定了188个DEG (97个上调,91个下调).
上调的DEG与细胞外空间,细胞因子-细胞因子受体相互作用和TNF信号传递有关.
降低调节的DEG与二碳酸盐运输,代谢和近接管管的功能有关.
有改变表达的关键基因包括CCL20,CDC20,CXCL1,CXCL2,CXCL5,NEK2,PPBP (上调) 和CXCL12 (下调).

结论:

八个基因 (CCL20,CDC20,CXCL1,CXCL12,CXCL2,CXCL5,NEK2,PPBP) 被提议作为CRC的潜在诊断指标.
已确定的途径 (细胞因子-细胞因子受体相互作用,TNF信号传递,代谢,二碳酸盐回收) 可能在CRC的发展和进展中发挥作用.
这项研究为中国人群特有的CRC病因和进展提供了新的见解.

关键词:

结肠直肠癌是一种癌症.地理地质组织 (GEO) 是指地理地质组织.这就是TNF信号通路.生物标志物生物标志物中国的人口中国人口.表达方式表达方式表达方式表达

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