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Updated: May 16, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

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整合蛋白质溶解向金马 (PROTACs) 与输送系统,以实现更高效,更精确的向蛋白质降解

Jiachan Lin1, Zirui Chen1, Dan Zhang1

  • 1School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen, 518107, China.

Macromolecular rapid communications
|April 4, 2025
PubMed
概括

使用向蛋白质分解的仿真体 (PROTACs) 进行向蛋白质降解 (TPD) 提供了新的癌症治疗选择. 交付系统的创新正在提高PROTAC的疗效,并减少毒性,以获得更好的临床转化.

关键词:
这就是 PROTACs.药物输送系统是药物输送系统.纳米颗粒是一种纳米粒子.作为一种前药物,它是一种前药物.蛋白质降解 蛋白质降解

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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

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