基底时的临床和解剖学特征:一个系统的审查
Fabrice Bartolomei1,2, Francesca Pizzo1,2, Stanislas Lagarde1,2
1APHM, Timone Hospital, Epileptology and Cerebral Rhythmology, Marseille, France.
概括
基本叶 (TLE) 发作往往伴有语言和运动症状,与其他TLE形式不同. 使用先进成像和SEEG进行准确的诊断可以改善这种未被认可的亚型的外科治疗结果.
科学领域:
- 神经学 神经学
- 发病学 (Epileptology) 是一个专业的学科.
- 神经科学是一个神经科学.
背景情况:
- 基本叶 (TLE) 是一个未被认可的子类型.
- 了解其独特的临床和解剖特征对于诊断和治疗至关重要.
- 从其他TLE形式区分基底TLE仍然是一个诊断挑战.
研究的目的:
- 描述基底时发作的临床半学和解剖相关性.
- 与其他TLE亚型相比,确定基底TLE的区别特征.
- 评估基底TLE患者的手术后结果.
主要方法:
- 按照PRISMA指南进行系统的文献审查.
- 包括临床,解剖学和神经生理学研究,优先考虑视频EEG,SEEG和手术结果.
- 来自15项研究 (83名患者) 的半理学特征,成像发现和术后结果的分析.
主要成果:
- 基本发作通常表现为语言障碍和运动现象,与其他TLE相比,情绪/感官征兆较少.
- SEEG局部化了发性区域,主要到状回环,鼻腔皮层和副海马区域.
- 57%的患者在手术后获得了Engel Class I结果,这表明治疗有效.
结论:
- 准确的基底TLE诊断,得到先进的成像和SEEG的支持,可以显著改善控制.
- 由于与其他TLE亚型重叠的立体学,诊断挑战仍然存在.
- 需要进一步的研究来完善诊断标准,并了解的基本时的功能影响.
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