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Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
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在慢性辅助性中耳炎中感染Pseudomonas aeruginosa
Artono Artono1, Nyilo Purnami2, Edi Handoko3
1Doctoral Program, Faculty of Medicine, Airlangga University, Surabaya, Indonesia.
Infection & chemotherapy
|April 4, 2025
概括
Pseudomonas aeruginosa 是慢性性中耳炎 (CSOM) 的常见原因. 酸有效地抑制和消灭P. aeruginosa生物膜,为CSOM提供了潜在的治疗策略.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 微生物学 微生物学
- 传染性疾病 传染性疾病
背景情况:
- 慢性性中耳炎 (CSOM) 是发展中国家听力损失的重要原因.
- 抗生素耐药性增加与不适当的抗生素使用有关.
- 生物膜形成细菌,特别是Pseudomonas aeruginosa,经常与CSOM有关,导致患者的治疗结果较差.
研究的目的:
- 为了描述CSOM患者的细菌概况.
- 评估抗生素敏感性模式.
- 为了评估乙酸对Pseudomonas aeruginosa的抗菌效果.
主要方法:
- 从CSOM患者样本中进行细菌分离和鉴定.
- 使用Kirby Bauer光盘扩散方法进行抗生素敏感性测试.
- 在实验室中通过微型板测试对酸抗膜活性 (MBIC和MBEC) 的评估.
主要成果:
- 在45个CSOM样本中的31个中,Pseudomonas aeruginosa是主要的格拉姆阴性细菌.
- 对美罗,阿米卡辛,皮佩拉西林-塔扎巴克坦,塞夫塔齐迪姆和赛福拉-苏尔巴克坦观察到高敏感率 (93.33%).
- 酸显示出显著的抗生物膜活性,最低生物膜抑制度 (MBIC) 为0.16%,最低生物膜消除度 (MBEC) 为0.31%.
结论:
- P. aeruginosa是CSOM中普遍存在的病原体,对特定的抗生素,包括美罗和阿米卡辛,表现出敏感性.
- 酸有效地抑制P. aeruginosa生物膜的形成在0.16%和消除生物膜在0.31%.
- 酸在CSOM中为管理P. aeruginosa生物膜提供了一个有前途的治疗剂.
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