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Updated: May 16, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

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GPR84的最小结构变化 完全激动因子 导致功能切换到逆激动因子

Loukas Ieremias1, Asmita Manandhar1, Katrine Schultz-Knudsen1

  • 1Department of Drug Design and Pharmacology, Faculty of Health, University of Copenhagen, 2100 Copenhagen Ø, Denmark.

Journal of medicinal chemistry
|April 4, 2025
PubMed
概括

研究人员发现,微小的结构变化可以将GPR84激动剂转化为逆激动剂. 这导致开发出强大的GPR84逆agonists和对抗剂治疗炎症疾病.

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