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准UAF1 通过抑制APP/NLRP3轴介导的烧亡和亡来缓解神经毒性

Ling Cheng1, Xianguang Meng2, Dandan Tian1

  • 1Department of Neurology Medicine, The Second Hospital of Shandong University, Jinan, Shandong Province, 250033, China.

Neurochemical research
|April 4, 2025
PubMed
概括

乌比基特异性蛋白酶1-关联因子1 (UAF1) 通过促进粉样β诱导的亡和亡,驱动阿尔茨海默病 (AD) 神经毒性. 抑制UAF1可以减少AD病理和认知衰退.

关键词:
阿尔茨海默氏症 (AD) 是一种疾病.细胞灭亡 (apoptosis) 是一种死亡的过程.亚博体育在线娱乐 亚博体育在线娱乐在NLRP3中,NLRP3是NLRP3中的一个.热灭菌的发生.在UAF1AF1中.

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