甲状腺功能测试和不同人群中的血清抗米勒尔激素,有任何关联吗? 一个系统的审查和元分析
Reza Amani-Beni1, Bahar Darouei1, Sara Ghadimi Nooran2
1Heart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Archives of gynecology and obstetrics
|April 4, 2025
概括
这项研究发现了抗米勒尔激素 (AMH) 和甲状腺功能之间的复杂联系. 虽然AMH和甲状腺刺激激素 (TSH) 显示出弱相关性,但AMH与其他甲状腺标志物如FT3和FT4有关.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 甲状腺学 甲状腺学
- 生物标志物研究 生物标志物研究
背景情况:
- 抗穆勒尔激素 (AMH) 是卵巢储备的一个关键指标.
- 甲状腺功能障碍很普遍,可能会影响生殖健康.
- 甲状腺功能标志物和AMH之间的关系需要进一步阐明.
研究的目的:
- 系统地审查和元分析AMH水平与甲状腺功能测试 (TFT) 和自身抗体之间的关联.
- 调查与甲状腺刺激激素 (TSH),自由T3 (FT3),自由T4 (FT4),T3,T4,甲状腺过氧化酶抗体 (TPOAb) 和甲状腺球蛋白抗体 (TgAb) 的相关性.
- 确定在不同女性群体中影响这些协会的潜在主持人.
主要方法:
- 在六个电子数据库中进行了全面的文献搜索.
- 包含的观察性研究检查了AMH与至少一个TFT,TPOAb或TgAb之间的相关性.
- 对40项涉及14009名参与者的研究数据进行了定量合成和元回归分析.
主要成果:
- 亚美水平最初与TSH没有显著的相关性,但在调整出版偏差后出现了小的正相关性.
- 在AMH和FT3 (r=0.177) 和FT4 (r=0.058) 之间发现了显著的正相关性.
- 在AMH和T3 (r=-0.202) 和T4 (r=-0.216) 之间观察到负相关性. 在正常人群中,AMH与TPOAb正相关 (r=0.348). 没有发现与TgAb的显著相关性.
结论:
- 甲状腺功能标志物和AMH之间的关系是复杂的,并受到各种因素的影响.
- 雌激素,FT3,FSH,体重指数和FT4被确定为显著的调节剂.
- 需要进一步进行纵向研究,以了解不同生殖阶段和代谢特征的机制和临床影响.
更多相关视频
相关概念视频
Functions of Thyroid Hormones
2.4K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.4K
Synthesis and Regulation of Thyroid Hormones
4.0K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.0K
Hormonal Regulation
43.0K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
43.0K
Major Hormones and Their Functions
264
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
264
Target Cell Response to Hormones
2.8K
Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
2.8K
Hormones and Bone Tissue
2.5K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.5K


