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大麻素对免疫检查点抑制剂反应的影响:CCTG对个体患者数据的综合分析

Courtney H Coschi¹, Keyue Ding¹, Justin Tong²

¹Canadian Cancer Trials Group, Kingston, ON, Canada.

|April 4, 2025

概括

在接受双重免疫检查点抑制剂 (ICI) 的患者中,使用大麻素可以改善无进展生存率,但不能改善整体生存率. 这项研究支持与ICI联合治疗一起安全使用大麻素.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
药理学药理学是指药理学的学科.

背景情况:

免疫检查点抑制剂 (ICI) 是有效的癌症治疗方法.
大麻素可能会抑制T细胞激活,可能会抵消ICI的疗效.
大麻素使用和双重ICI治疗之间的相互作用尚未得到充分理解.

研究的目的:

在涉及双重ICI治疗的试验中调查大麻素使用对患者结果和不良事件的影响.
确定使用大麻素是否会影响反应,生存或与免疫相关的不良事件 (irAEs).

主要方法:

从4个加拿大癌症试验组 (CCTG) 试验中汇集的个人患者数据,涉及双 ICI ± 化疗 (n=684).
统计分析 (Cochran-Mantel-Haenszel,日志等级测试) 与大麻素使用与结果相关.
评估的结果包括最佳总体反应 (BOR),免疫BOR (iBOR),无进展生存 (PFS),免疫PFS (iPFS),总体生存 (OS) 和irAEs.

主要成果:

9.5%的患者使用大麻素,在基线时为4.7%.
基线大麻素使用与显著改善的iPFS相关 (p=0.05).
对于iBOR,PFS,OS或irAE发病率与基线大麻素使用没有发现显著的关联.

结论:

在双 ICI 治疗中使用大麻素改善的 iPFS 并没有导致改善 OS.
在ICI联合治疗的背景下,使用大麻素似乎是安全的.
进一步的研究可能会澄清大麻素在癌症免疫治疗中的作用.

关键词:

这是一种抗CTLA-4的药物.这种抗PD-1药物.抗PD-L1的抗PD-L1 的免疫治疗是一种免疫疗法.大麻素是一种大麻素.达尔瓦卢马布 (Durvalumab) 是一种耐药的药物.免疫检查点抑制剂免疫检查点抑制剂这就是为什么特雷米利木马布.

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