2018 - 2023年欧洲肠道病毒流通的流行病学和临床见解:多中心追溯监测研究
Sten de Schrijver1, Emiel Vanhulle1,2, Anne Ingenbleek3
1Centre for Infectious Disease Control, Dutch National Public Health Institute, Bilthoven, The Netherlands.
The Journal of infectious diseases
|April 4, 2025
概括
肠道病毒 (EV) 导致严重的每年爆发,特别是在儿童中. 这项研究追踪了2018-2023年欧洲的EV循环和临床症状,并指出季节性变化和新生儿病例增加.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 肠道病毒 (EV) 是每年爆发的重要原因,导致严重感染,特别是在幼儿中.
- 了解EV循环模式和临床表现对于公共卫生干预至关重要.
研究的目的:
- 在2018年至2023年期间调查欧洲肠道病毒的循环,年龄分布和临床表现.
- 确定EV类型及其相关临床结果的趋势,包括流行后的变化.
主要方法:
- 从16个欧洲国家 (2018-2023) 收集了有关EV检测,样本类型,年龄组和临床表现的数据.
- 分析重点是每年报告的十种最常见的EV类型,利用监控网络的汇总数据.
主要成果:
- 超过563,000个EV测试产生了5.9%的阳性,确定了42种类型,其中埃科病毒 (E) 30,萨基病毒 (CV) A6和EV-D68是常见的.
- 观察到季节性检测 (夏季到秋季) 和标本类型 (便到呼吸道) 的转变.
- 神经症状很常见,特别是在EV-A71,CVB4,CVB5,E6,E9,E11,E18和E30的情况下. 新生儿感染在CVB4,CVB5,E9,E11和E18.18方面显著. CVA6与HFMD有关,EV-D68与呼吸系统疾病有关,并在22例病例中发生.
结论:
- 肠道病毒在欧洲继续广泛传播,导致严重疾病,特别是在新生儿中,某些类型在流行后显著复苏.
- 持续监测对于监测不断变化的EV循环,年龄人口统计和临床表现至关重要,包括非脊髓灰质炎EV相关.
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