微阵列补丁疫苗用于伤寒结合疫苗:全球性成本效益分析
Marina Antillon1, Anna Verjans1, Fayad El Sheikh2
1Swiss Tropical and Public Health Institute, Kreuzstrasse 2, 4123 Allschwil, Switzerland; University of Basel, Petersplatz 1, P. O. Box, 4001, Basel, Switzerland.
Vaccine
|April 4, 2025
概括
新型伤寒联合疫苗微阵列补丁 (TCV-MAP) 可以避免数百万病例和死亡. TCV-MAP显示出成本效益,特别是在撒哈拉以南非洲,区域部署提供了显著的价值.
科学领域:
- 全球健康 全球健康
- 疫苗学 疫苗学 疫苗学
- 卫生经济学 卫生经济学
背景情况:
- 目前通过针和注射器 (TCV-N&S) 施用的伤寒联合疫苗 (TCV) 在难以接触的人群中面临覆盖范围的限制.
- 一种新的伤寒结合疫苗呈现方式,微阵列贴片 (TCV-MAP),正在开发中,有可能改善疫苗的发放和覆盖率.
研究的目的:
- 评估与单独使用TCV-N&S相比,TCV-MAP的成本效益.
- 评估TCV-MAP对133个中低收入至中高收入国家的健康结果和医疗保健成本的影响.
主要方法:
- 从20年 (2033-2052) 的医疗保健角度进行了全球扩展的成本效益分析.
- 该分析认为TCV-MAP的成本是TCV-N&S的1.33到3倍.
- 计算了增量成本效益比率,并与成本效益值进行了比较,并对五个国家进行了地方分析.
主要成果:
- 与单独使用TCV-N&S相比,在全国范围内推出TCV-MAP可以避免额外的520万例病例,47,000例死亡和240万个DALY,额外成本为35亿美元.
- 在33%的研究国家中,TCV-MAP的成本效益被证明是有效的,在撒哈拉以南非洲,这一比例达到78%.
- 与全国推广相比,TCV-MAP的地方实施可以避免2-15%的案件,而相比全国推广的额外成本不到1-3%,从而提高价值.
结论:
- TCV-MAP是一种潜在的成本效益策略,可以提高伤寒联合疫苗的覆盖率,特别是在资源有限的环境中.
- TCV-MAP的价格是一个关键因素;较低的价格和战略性的区域或次国家实施提高了他们的价值主张.
- 有针对性的TCV-MAP部署可以显著改善公共卫生结果并减少疾病负担,特别是在撒哈拉以南非洲等高发病率地区.
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