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在化疗治疗后,老年乳腺癌幸存者的自我报告认知功能
Rachel Kim1, Julia Peña1, Kai-Ping Liao1
1Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Breast (Edinburgh, Scotland)
|April 4, 2025
概括
化疗对老年乳腺癌幸存者的认知功能没有显著影响. 这项研究发现,前期化疗与治疗后多年自我报告的认知障碍之间没有联系.
科学领域:
- 在瘤学瘤学.
- 神经科学是一个神经科学.
- 老年病的医生 老年病的医生
背景情况:
- 认知功能是老年人,特别是癌症幸存者关注的一个问题.
- 化疗对乳腺癌幸存者的认知长期影响需要进一步调查.
研究的目的:
- 为了评估老年乳腺癌幸存者的自我报告的认知功能.
- 在这个人群中确定先前化疗和认知障碍之间的关联.
主要方法:
- 使用了癌症治疗-认知功能的功能评估 (FACT-CogV3) 仪器.
- 使用回归模型分析了1594名乳腺癌幸存者 (65岁以上) 的数据.
- 认知障碍被定义为PCI子得分低于54.认知障碍是指PCI子得分低于54.
主要成果:
- 高龄 (80岁以上) 和抑郁症与认知功能下降有关.
- 高等教育与更好的认知成绩相关.
- 之前的化疗并不是自我报告认知障碍的显著预测因素 (OR1.49,p=0.06).
结论:
- 在老年乳腺癌幸存者中,自我报告的认知障碍与辅助化疗没有显著的联系.
- 这个队列中的认知功能与年龄和抑郁症更强烈相关.
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