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绿色框架中的协同化疗免疫疗法:以自然植物多糖为基础的纳米粒子,对pH值有反应

Zhen Lin¹, Ruyu Cao¹, Fan Nie¹

¹State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China.

Biomaterials advances

|April 4, 2025

概括

金色果的多糖和基醇被制成适应pH的纳米颗粒 (HK@PPP-BDBA),用于联合化疗-免疫疗法. 这种新型纳米药物有效地抑制了癌细胞的生长,并增强了抗瘤免疫力.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
自然产品化学自然产品化学

背景情况:

传统的癌症疗法面临着局限性,需要新的治疗方法.
天然产品,如霍诺基醇 (HK) 和植物多糖类,对抗癌药物开发有前途.
多糖提供生物相容的药物输送平台,具有免疫刺激性质.

研究的目的:

开发适应pH值的纳米颗粒 (HK@PPP-BDBA) 集成Honokiol (HK) 和金色果多糖化物 (PPP) 用于协同化学免疫疗法.
描述纳米粒子和阐明它们的组装机制.
评估HK@PPP-BDBA对癌症的体外和体内疗效.

主要方法:

使用金色果多糖化物 (PPP) 和-1,4-二博酸 (BDBA) 制备响应pH的纳米粒子 (HK@PPP-BDBA).
纳米粒子组装的全面化学表征和计算模拟.
对MCF-7和HeLa细胞的细胞毒性的体外评估,包括反应性氧物种 (ROS) 生产和亡诱导.
在体内研究评估瘤生长抑制,癌细胞迁移和免疫反应调节 (树突细胞成熟,共刺激分子表达).

主要成果:

在试验室和体内,HK@PPP-BDBA纳米颗粒显著抑制了癌细胞的增殖和迁移.
红 (HK) 诱导了瘤细胞中的ROS产生和亡.
金色果多糖 (PPP) 促进树突细胞成熟,增强抗瘤免疫反应.
这些纳米颗粒表现出pH响应的行为,并促进了协同化学免疫疗法.

结论:

HK@PPP-BDBA纳米粒子代表了协同化学免疫疗法的有前途的平台.
这种方法利用Honokiol的抗癌特性和天然多糖的免疫调节能力.
该研究强调了基于天然产品的纳米药物在推进癌症治疗策略方面的潜力.

关键词:

化疗化疗是一种化学疗法.霍诺基奥尔 (Honokiol) 是一个免疫治疗是一种免疫疗法.多糖类多糖化物.对于pH的响应性

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