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胞患者的微RNA:一个系统的审查
Zahra Razavi1, Nafiseh Esmaeili1, Saba Katebian1
1Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.
International immunopharmacology
|April 4, 2025
概括
微RNA在诊断和预测严重的自身免疫性水泡性疾病 - - 尾虫病方面表现有前途. 需要进一步的研究来确认它们在皮肤病学中的临床应用.
科学领域:
- 皮肤病学 皮肤病学
- 自免疫性疾病 自免疫性疾病
- 分子生物学分子生物学
背景情况:
- 菲古斯是一种严重的自身免疫性水泡性疾病 (AIBD) 的一组.
- 微RNAs (miRNAs) 在虫病原发生中的作用是皮肤学研究的一个新兴领域.
研究的目的:
- 系统地审查microRNAs在pemphigus病的诊断和严重程度评估中的作用.
主要方法:
- 在PubMed,Scopus,Embase和Web of Science上进行了系统的文献搜索.
- 包括1990年至2025年2月发表的研究.
主要成果:
- 在系统性审查中确定了8项研究.
- 发现18种类型的微RNA的表达水平与健康个体相比,在尾虫患者中显著不同.
结论:
- 微RNA可以作为潜在的生物标志物用于虫的诊断和疾病进程的预测.
- 需要对这些microRNA发现进行临床验证.
关键词:
自身免疫性公牛性疾病尾虫 (Pemphigus) 是一种类型的尾虫.庞菲古斯 (Pemphigus foliaceus) 是一种状的植物.庞菲古斯 (Pemphigus vulgaris) 是一种常见的植物.这是一个微型RNA.更多相关视频
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01:22MicroRNAs
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
01:22MicroRNAs
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
01:22MicroRNAs
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...