在大脑动脉中SARS-CoV-2尖端蛋白的表达:对出血性中风的影响mRNA疫苗接种后的疫苗接种
Nakao Ota1, Masahiko Itani2, Tomohiro Aoki3
1Stroke Center, Department of Neurosurgery, Sapporo Teishinkai Hospital, Sapporo, Japan.
概括
在接种疫苗后的17个月内,在接种疫苗的个体的大脑动脉中检测到长期存在的SARS-CoV-2尖端蛋白,这引发了安全问题. 需要进一步的研究来了解mRNA疫苗的生物分布和长期影响.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 在COVID-19大流行期间,mRNA疫苗 (例如,BNT162b2,mRNA-1273) 的快速部署.
- 虽然短期的安全性已经确立,但罕见的不良事件,如出血性中风发生.
- 长期生物分布和mRNA疫苗的影响需要进一步研究.
研究的目的:
- 为了研究SARS-CoV-2尖端蛋白在出血性中风患者的大脑组织中的长期存在.
- 检查mRNA疫苗接种与大脑动脉中尖端蛋白质存在之间的潜在关联.
主要方法:
- 对19例出血性中风病例 (2023-2024) 的回顾性分析.
- 针对SARS-CoV-2尖峰和核囊蛋白的免疫组化学染色.
- 在现场杂交以确定尖端蛋白的来源 (疫苗与病毒).
主要成果:
- 在43.8%的接种疫苗的患者中检测到尖端蛋白质,主要是在接种疫苗后17个月的脑动脉内脏中.
- 在尖端阳性血管中观察到的炎症细胞透 (CD4+,CD8+,CD68+).
- 尖端蛋白质阳性仅在女性患者中 (P=0.015);没有检测到核囊蛋白.
结论:
- 在mRNA疫苗接种后的大脑动脉中长时间存在SARS-CoV-2尖端蛋白.
- 研究结果表明,对mRNA疫苗的生物分布和长期安全性存在潜在担忧.
- 对于全面的安全评估,迫切需要进行全球复制研究.
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