高盐饮食因果上增加了与代谢功能障碍相关的脂肪性肝病风险:一项双向的门德尔随机化研究
Qi Liu1, Yuyang Liu2, Hui Feng3
1Faculty of Hepato-Pancreato-Biliary Surgery, The First Medical Center of Chinese People's Liberation Army General Hospital, Beijing, China; Institute of Hepatobiliary Surgery, Key Laboratory of Digital Hepatobiliary Surgery of Chinese People's Liberation Army, Beijing, China; Medical School of Chinese People's Liberation Army, Beijing, China.
Nutrition research (New York, N.Y.)
|April 4, 2025
概括
高盐摄入因果性地增加了与代谢功能障碍相关的脂肪性肝病 (MASLD) 的风险. 减少饮食盐对于预防MASLD和肝脏健康至关重要. 这项研究为这种联系提供了遗传证据.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
- 营养流行病学 营养流行病学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 影响全球25%的人口.
- 高盐摄入量被怀疑是MASLD的危险因素,但尚未得到证实.
- 盐消费和MASLD之间的因果关系需要进行严格的调查.
研究的目的:
- 调查习惯盐摄入量与MASLD风险之间的因果关系.
- 为了确定基因倾向于更高的盐摄入量是否会增加MASLD的易感性.
- 为了探索反向因果关系:MASLD是否影响盐的摄入量.
主要方法:
- 双向门德尔随机化 (MR) 分析使用遗传变异作为仪器变量.
- 利用来自英国生物银行和MASLD队伍的大规模全基因组关联研究数据.
- 采用逆方差权衡和灵敏度分析 (MR-Egger,MR-PRESSO) 来确保稳定性.
主要成果:
- 预先的MR分析显示,较高的盐摄入量对增加的MASLD风险具有显著的因果关系 (ORs从1.538到2.094不等).
- 灵敏度分析证实了低异质性和没有显著的质性.
- 反向MR分析没有发现MASLD对盐摄入有因果影响的证据.
结论:
- 添加到食物中的食盐是发展MASLD的因果风险因素.
- 这些发现支持公共卫生建议减少盐摄入量以预防MASLD.
- 减少盐分的策略对于促进肝脏健康和管理MASLD至关重要.
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