患有注意力缺陷过度活动障碍和自闭症谱系障碍的儿童的肠道微生物群差异以及益生菌补充剂的影响:随机对照试验
Nil Novau-Ferré1, Christopher Papandreou2, Meritxell Rojo-Marticella3
1Nutrition and Metabolic Health Research Group (NuMeH). Department of Biochemistry and Biotechnology, Rovira i Virgili University (URV), 43201 Reus, Spain; Institute of Health Pere Virgili (IISPV), 43204 Reus, Spain; Center of Environmental, Food and Toxicological Technology - TecnATox, Rovira i Virgili University, 43201 Reus, Spain.
Research in developmental disabilities
|April 4, 2025
概括
患有注意力缺陷多动障碍 (ADHD) 和自闭症谱系障碍 (ASD) 的儿童的肠道微生物组成不同. 益生菌补充改善了ASD的肠道多样性,并在两个神经发育障碍中调节了特定细菌.
科学领域:
- 微生物组研究的研究.
- 神经发育障碍 神经发育障碍
- 儿科卫生保健 儿科卫生保健
背景情况:
- 肠道微生物群在ADHD和ASD等神经发育障碍中起着至关重要的作用.
- 新出现的证据将肠道微生物组组成与这些情况联系起来.
研究的目的:
- 为了比较患有ADHD和ASD的儿童之间的肠道微生物组成.
- 评估益生菌补充剂对这些群体肠道微生物群的影响.
主要方法:
- 一项为期12周的随机,双盲,安慰剂对照试验,涉及80名患有多动症或自闭症的儿童 (5-14岁).
- 使用16S rRNA基因测序分析便样本,以评估肠道微生物群的变化.
- 微生物多样性指数 (Chao 1,Fisher's alpha,Shannon) 和种群丰度的比较.
主要成果:
- 确定了22种不同的微生物种群,区分ADHD和ASD.
- 在ADHD中,克洛斯特里迪亚菌,鲁米诺科卡菌和拉克诺斯皮拉菌的含量更高;在ASD中,细菌菌,细菌和动菌菌的含量更高.
- 益生菌补充剂增加了ASD中的微生物多样性,并减少了与胃肠道问题和焦虑相关的特定种群.
结论:
- 肠道微生物群的变异与ADHD和ASD有关.
- 益生菌可以有利地改变患有这些疾病的儿童的肠道微生物群组成.
- 这些发现支持针对神经发育障碍的微生物组向疗法.
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