药物感知调解疾病感知与胃肠道癌症患者口服抗癌剂的坚持之间的关联:一个横截面研究
Yongfeng Chen1, Marques Shek Nam Ng2, Xulian Wei3
1The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong; People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
概括
疾病的感知影响胃肠道癌症患者的口服抗癌药物的坚持,部分是通过药物的自我有效性. 改善患者的感知可以提高患者的坚持和治疗结果.
科学领域:
- 在瘤学瘤学.
- 行为科学 行为科学
- 健康心理学 心理健康心理学
背景情况:
- 在胃肠道癌症中,口服抗癌药物的低最佳坚持是显著的问题,导致治疗效益降低和死亡率增加.
- 常识自我调节模型表明患者对疾病的看法和治疗影响的坚持,但这种联系在这个人群中未得到充分探索.
研究的目的:
- 调查疾病感知是否影响口服抗癌药物的坚持.
- 探索药物感知在疾病感知和坚持之间关系中的调解作用.
主要方法:
- 一项涉及中国253名胃肠道癌症患者的多中心横截面研究.
- 经过验证的调查问卷评估了疾病的感知,药物信仰,自我有效性和坚持.
- 进行调解分析以检查间接影响.
主要成果:
- 更糟糕的负面疾病感知与更高的关注,更低的自我效能和更差的坚持相关.
- 疾病的感知直接和间接地影响了通过药物自我疗效的坚持.
- 药物自我有效性与药物坚持有积极的关联.
结论:
- 药物的自我有效性部分介于疾病感知和坚持之间的关系.
- 旨在培养积极的疾病感知的干预措施可能会改善药物的自我有效性和药物坚持.
- 疾病感知的认知和情感方面都需要注意.
相关概念视频
01:25Factors Influencing Drug Absorption: Disease States and Pharmacology
467
Multiple disease states can significantly influence the oral drug absorption process by affecting blood flow and the functionality of the gastrointestinal (GI) system. Various GI diseases, including conditions that alter GI motility, such as diarrhea, decreased acid secretions (achlorhydria), and infections, have been associated with reduced drug absorption.
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
467
01:17Assessment of the Gastrointestinal System I: Subjective Data
160
Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems...
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems...
160
01:29Assessment of the Gastrointestinal System II: Health Perception Pattern
87
Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health Perception Patterns
Health perception patterns offer valuable insights into a patient's lifestyle habits and how they may impact their GI health. These patterns include:
Health Perception Patterns
Health perception patterns offer valuable insights into a patient's lifestyle habits and how they may impact their GI health. These patterns include:
87
01:19Drug Absorption: Factors Affecting GI Absorption
3.9K
The process of oral drug absorption can be influenced by several factors. Weakly acidic drugs tend to be absorbed more readily from the stomach due to their nonionized state. However, absorption may be less efficient in the upper intestine, where drugs are often ionized. Interestingly, despite the stomach's apparent advantage for drug absorption, its mucous layer can hinder diffusion. Its surface area is also smaller than the intestine's, which can further slow down the absorption rate.
3.9K
01:27Nursing Ethical Principles II
935
Ethical principles are essential in guiding nurses to fulfill their responsibilities, focusing on the quality of nursing care and decision-making. These principles, including autonomy, beneficence, non-maleficence, justice, and fidelity, shape the ethical framework within healthcare settings.
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's...
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's...
935
01:20Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
179
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
179