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聚乙烯微粒暴露对雄性小鼠的精子细胞分化和生殖终点的影响

Rong Shen¹, Peng Xia¹, Yanan Guo¹

¹School of Basic Medical Sciences, Lanzhou University, Gansu, 730000, China.

Environmental pollution (Barking, Essex : 1987)

|April 4, 2025

概括

聚乙烯纳米塑料 (PS) 在男性丸中积累,损害生育能力和精子细胞发育. 这项研究揭示了在小鼠中PS暴露引起的表观遗传变化和代谢干扰.

科学领域:

环境健康环境健康
生殖毒理学生殖毒理学
纳米毒理学研究

背景情况:

微塑料污染是一个日益严重的环境问题,可能会对人类健康产生影响.
微塑料,特别是纳米塑料在男性生殖系统上的积累和影响尚不清楚.

研究的目的:

研究0.1微米聚烯 (PS) 纳米塑料对小鼠雄性生殖系统的影响.
探索潜在的机制,包括代谢重编程和表观遗传修饰.

主要方法:

小鼠连续暴露在0.1微米PS的3个月.
评估生育能力,精子分化,以及丸组织中的PS积累.
分析了丸组织和GC-1细胞中的代谢途径,组胺甲基化和自相关途径.

主要成果:

0.1微米PS在丸组织和精子积,而1微米PS没有.
暴露于PS导致生育能力降低,并抑制了精子的分化.
观察到组织素甲基化,自和代谢途径,特别是糖分解的显著变化.

结论:

长期暴露在0.1微米PS下会损害小鼠的雄性生育能力和精子生成细胞分化.
表观遗传修饰和代谢失调,包括自功能受损,有助于PS诱导的生殖毒性.
准糖解路径可能提供一个策略,以减轻PS诱导的生殖功能障碍.

关键词:

表观遗传修饰是一种表观遗传修饰.葡萄糖溶解是什么? 葡萄糖溶解微塑料是一种微塑料.生殖系统的繁殖系统.精子发生细胞分化.

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