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一个患有脑膜炎的新生儿是由益生菌相关的Clostridium butyricum引起的

Yanfang Jiang¹, Jiaxu Yang², Yong Liu¹

¹Genetic Diagnosis Center, The First Hospital of Jilin University, Changchun, Jilin Province, China.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

|April 4, 2025

概括

一名早产婴儿因使用益生菌而患上了Clostridium butyricum脑膜炎. 这一案例凸显了益生菌在新生儿,特别是早产婴儿中的风险,强调了谨慎的管理.

科学领域:

微生物学微生物学
新生儿医学新生儿医学
传染性疾病传染性疾病

背景情况:

Clostridium butyricum 是一种常见的肠道细菌,被用作益生菌.
新生儿,特别是早产婴儿,是感染的脆弱人群.

研究的目的:

在新生儿中报告第一个Clostridium butyricum脑膜炎病例.
要突出与早产婴儿的益生菌管理相关的潜在风险.

主要方法:

诊断包括脑脊液 (CSF) 生物化学测试和神经成像.
在CSF中,下一代代基因组测序确定了C. butyricum.
遗传学分析证实了传染性菌株的益生菌起源.

主要成果:

一个26天的早产新生儿被诊断出患有C. butyricum脑膜炎.
婴儿接受了抗生素治疗,使用了万科米辛和美罗.
在抗生素治疗后,CSF概况得到改善.

结论:

这是首次报告新生儿感染C. butyricum的病例.
在新生儿中服用益生菌需要谨慎,特别是在高危人群中.
过早出生的婴儿,有中央静脉导管的婴儿和肠道疾病的风险增加.

关键词:

这是一种Clostridium butyricum.脑膜炎是一种脑膜炎.新生儿新生儿新生儿益生菌益生菌益生菌

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